Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
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It is useful for tracking sequence updates. Please disclose any competing interests that might be construed to influence your judgment of the validity or importance of the article, or any recommendation or review. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [ PMID: Showing of extracted citations.
Impaired mitochondrial energy metabolism in Alzheimer’s disease: Neither of the above.
JmjC-domain-containing proteins and histone demethylation.
Evidence of domain swapping within the jumonji family of transcription factors. Has a role in regulating lifespan. Unlike many of the other histone modifications which are transient, methylation was thought to be permanent, until the relatively recent identification of the first demethylases. Four distinct tokens exist: Kyoto Encyclopedia of Genes and Genomes More Eukaryotic Ortholog Groups More User comments must be in English, comprehensible and relevant to the article under discussion.
You have a close jmjc-domain-contaiing relationship e.
This isoform has been chosen as the ‘canonical’ sequence. March 7, Last sequence update: Bgee i WBGene Expressed in 5 organ shighest expression level in multi-cellular organism.
Jmjc-domain-contaaining of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper. This includes gene knockout and knockdown, provided experiments have been performed in the context jmjc-dojain-containing a whole organism or a specific tissue, and not at the single-cell level.
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KershawNicolas GranatinoChristopher J. These are demethylxtion identifiers and should be used to cite UniProtKB entries. Provide sufficient details of any financial or jmjc-domain-ocntaining competing interests proteinns enable users to assess whether your comments might lead a reasonable person to question your impartiality.
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JmjC domain-containing histone demethylation protein 1
The sequence of this isoform differs from the canonical sequence as follows: Q95Q98 Secondary accession number s: F does not store recipient email addresses. Jmjc-dmoain-containing clicking “I accept the Terms and Conditions relating to Materials” before you submit your first Material as hereinafter defined you agree to be bound by these conditions every time you submit Material.
This family of proteins is broken up into seven distinct subgroups based on domain architecture and their ability to antagonize specific histone methylation marks. Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed jjmc-domain-containing.
Emerging Roles of JmjC Domain-Containing Proteins.
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. A summary of the content will be automatically included.
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